DOUBLE STRANDED OLIGONUCLEOTIDE COMPOUNDS COMPRISING POSITIONAL MODIFICATIONS

Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Fur...

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Bibliographic Details
Main Authors BEIGELMAN, LEONID, AVKIN-NACHUM, SHARON, FEINSTEIN, ELENA
Format Patent
LanguageEnglish
French
Published 24.09.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Further disclosed is a method for the synthesis of threose nucleic acid phosphoramidites and methods of use thereof. La présente invention concerne des molécules d'ARN à double brin qui ont été modifiées pour présenter une des caractéristiques suivantes : une activité accrue, une stabilité améliorée aux nucléases, une activité hors cible réduite et/ou une immunogénicité réduite. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des procédés d'utilisation de celles-ci. L'invention concerne en outre un procédé de synthèse de phosphoramidites d'acides nucléiques à base de thréose et des procédés d'utilisation de ceux-ci.
Bibliography:Application Number: CA20112818024