IMPROVED GLYCOLIC ACID FERMENTATIVE PRODUCTION WITH A MODIFIED MICROORGANISM

The present invention is related to a method for the fermentative production of glycolic acid, its derivatives or precursors, comprising the culture of an Escherichia coli strain in an appropriate culture medium comprising a carbon source, and the recovery of glycolic acid in the medium, wherein sai...

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Bibliographic Details
Main Authors DISCHERT, WANDA, BESTEL-CORRE, GWENAELLE, COLOMB, CEDRIC
Format Patent
LanguageEnglish
French
Published 01.03.2012
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention is related to a method for the fermentative production of glycolic acid, its derivatives or precursors, comprising the culture of an Escherichia coli strain in an appropriate culture medium comprising a carbon source, and the recovery of glycolic acid in the medium, wherein said E. coli strain is modified to improve the conversion of orotate into orotidine 5'-P. The invention is also related to the modified E. coli strain, showing an improved conversion of orotate into orotidine 5'-P, and optionally that was furthermore modified for an improved glycolic acid production.
Bibliography:Application Number: CA20102808140