LUMINESCENT DYES WITH A WATER-SOLUBLE INTRAMOLECULAR BRIDGE AND THEIR BIOLOGICAL CONJUGATES

Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crossli...

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Main Authors MENG, QINGLIN, LIAO, JINFANG, GUO, HAITAO, DUBROVSKY, TIMOTHY, ABRAMS, BARNABY, DIWU, ZHENJUN
Format Patent
LanguageEnglish
French
Published 10.01.2017
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Summary:Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive fluorescent dyes, their biological conjugates and uses. La présente invention concerne des colorants chimiquement réactifs qui sont réticulés intramoléculairement avec un pont hydrosoluble, leurs conjugués biologiques et leurs applications. Les colorants fluorescents réactifs qui présentent un pont hydrosoluble sont supérieurs à ceux des conjugués des colorants spectralement non réticulés ou des colorants qui sont réticulés avec un pont hydrophobe. L'invention concerne des colorants fluorescents réactifs, leurs conjugués biologiques et leurs applications.
Bibliography:Application Number: CA20112806025