NOVEL SELF-REACTIVE ARMS AND PRODRUGS COMPRISING SAME

The present invention relates to a compound of general formula (I) in which: - X is OH, NH2, NHOH or RNH, wherein R may be a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, - Y is H, or an electron-withdrawing group, in particular selected from NO2, CF3 or a halogen, - R1 and R2...

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Bibliographic Details
Main Authors THOMAS, MICKAEL, PAPOT, SEBASTIEN
Format Patent
LanguageEnglish
French
Published 22.10.2019
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The present invention relates to a compound of general formula (I) in which: - X is OH, NH2, NHOH or RNH, wherein R may be a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, - Y is H, or an electron-withdrawing group, in particular selected from NO2, CF3 or a halogen, - R1 and R2 are H or a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, - F is a reactive functional group that can be activated by click chemistry. La présente invention concerne un composé de formule générale (I) dans laquelle : - X représente OH, NH2, NHOH ou R'NH avec R' pouvant représenter un radical alkyle en C1 à C10, linaire ou ramifié, saturé ou insaturé, - Y représente H, ou un groupe électro-attracteur, en particulier choisi parmi NO2, CF3 ou un halogène, - R1 et R2 représentent H ou un radical alkyle en C1 à C10, linaire ou ramifié, saturé ou insaturé, - F représente une fonction réactive activable par chimie click.
Bibliography:Application Number: CA20112799773