ANTIBODIES TO NON-FUNCTIONAL OLIGOMERIC P2X7 RECEPTORS

The invention relates to purinergic receptors, to antibodies and related fragments thereof for binding to said receptors, to production of said antibodies and fragments and to use of said antibodies and fragments for cancer detection and therapy. In particular the antibodies described bind specifica...

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Bibliographic Details
Main Authors GIDLEY-BAIRD, ANGUS, PILKINGTON, GLENN RONALD, BARDEN, JULIAN ALEXANDER
Format Patent
LanguageEnglish
French
Published 13.11.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:The invention relates to purinergic receptors, to antibodies and related fragments thereof for binding to said receptors, to production of said antibodies and fragments and to use of said antibodies and fragments for cancer detection and therapy. In particular the antibodies described bind specifically to non-functional P2X7 receptors expressed by live cells. La présente invention concerne des récepteurs purinergiques, des anticorps et fragments considérés de ceux-ci permettant la liaison auxdits récepteurs, la production desdits anticorps et fragments, et l'utilisation desdits anticorps et fragments pour la détection du cancer et la thérapie anticancéreuse. Les anticorps de la présente invention se lient spécifiquement aux récepteurs P2X7 non fonctionnels exprimés par des cellules vivantes.
Bibliography:Application Number: CA20102784345