PACLITAXEL/STEROIDAL COMPOUND

The present discloses a kind of paclitaxel steroid compound. Paclitaxel steroid compound is composed of paclitaxel and steroid lipid molecule by nonchemical bonding reaction, the molar ratio of paclitaxel and steroid is 1:0.2-4, preferably 1:0.25-2. The invention also discloses the preparation of pa...

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Main Authors ZHANG, PENGXIAO, GUO, RUIFANG, JIN, DUJIA, ZHOU, CUIPING, WANG, RENYUN, LIU, YULING, XIA, XUEJUN
Format Patent
LanguageEnglish
French
Published 03.05.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present discloses a kind of paclitaxel steroid compound. Paclitaxel steroid compound is composed of paclitaxel and steroid lipid molecule by nonchemical bonding reaction, the molar ratio of paclitaxel and steroid is 1:0.2-4, preferably 1:0.25-2. The invention also discloses the preparation of paclitaxel steroid compound and preparation of submicron emulsion, self-microemulsifying system and oral preparations. Steroid compound has greatly improved the paclitaxel solubility in oil phase and also provides a good intermediate carrier for new emulsion with high encapsulation efficiency, good safety and stable quality and for oral preparations with high bioavailability.
AbstractList The present discloses a kind of paclitaxel steroid compound. Paclitaxel steroid compound is composed of paclitaxel and steroid lipid molecule by nonchemical bonding reaction, the molar ratio of paclitaxel and steroid is 1:0.2-4, preferably 1:0.25-2. The invention also discloses the preparation of paclitaxel steroid compound and preparation of submicron emulsion, self-microemulsifying system and oral preparations. Steroid compound has greatly improved the paclitaxel solubility in oil phase and also provides a good intermediate carrier for new emulsion with high encapsulation efficiency, good safety and stable quality and for oral preparations with high bioavailability.
Author GUO, RUIFANG
JIN, DUJIA
LIU, YULING
ZHANG, PENGXIAO
WANG, RENYUN
XIA, XUEJUN
ZHOU, CUIPING
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– fullname: LIU, YULING
– fullname: XIA, XUEJUN
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Snippet The present discloses a kind of paclitaxel steroid compound. Paclitaxel steroid compound is composed of paclitaxel and steroid lipid molecule by nonchemical...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title PACLITAXEL/STEROIDAL COMPOUND
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