PACLITAXEL/STEROIDAL COMPOUND

The present discloses a kind of paclitaxel steroid compound. Paclitaxel steroid compound is composed of paclitaxel and steroid lipid molecule by nonchemical bonding reaction, the molar ratio of paclitaxel and steroid is 1:0.2-4, preferably 1:0.25-2. The invention also discloses the preparation of pa...

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Main Authors ZHANG, PENGXIAO, GUO, RUIFANG, JIN, DUJIA, ZHOU, CUIPING, WANG, RENYUN, LIU, YULING, XIA, XUEJUN
Format Patent
LanguageEnglish
French
Published 03.05.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present discloses a kind of paclitaxel steroid compound. Paclitaxel steroid compound is composed of paclitaxel and steroid lipid molecule by nonchemical bonding reaction, the molar ratio of paclitaxel and steroid is 1:0.2-4, preferably 1:0.25-2. The invention also discloses the preparation of paclitaxel steroid compound and preparation of submicron emulsion, self-microemulsifying system and oral preparations. Steroid compound has greatly improved the paclitaxel solubility in oil phase and also provides a good intermediate carrier for new emulsion with high encapsulation efficiency, good safety and stable quality and for oral preparations with high bioavailability.
Bibliography:Application Number: CA20102779316