SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula 1 (see formula 1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above c...

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Main Authors NAIR, LATHA G, HICKLIN, DANNY J, SEIDEL-DUGAN, CYNTHIA, LIU, YUAN, PAN, WEIDONG, SHIPPS, GERALD W., JR, VOSS, MATTHEW ERNST, SCAPIN, GIOVANNA, RINDGEN, DIANE, TIAN, YUAN, MACCOSS, MALCOLM, KULKARNI, BHEEMASHANKAR A, LAHUE, BRIAN ROBERT, SHIZUKA, MANAMI, GUZI, TIMOTHY J, NOMEIR, AMIN, MA, YAO, WANG, YAOLIN, GIBEAU, CRAIG R, BOGEN, STEPHANE L, KIROVA-SNOVER, MARGARITA, DOLL, RONALD J
Format Patent
LanguageEnglish
French
Published 15.12.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound of Formula 1 (see formula 1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. L'invention concerne un composé représenté par la formule (1) ou un sel, un solvate ou un ester pharmaceutiquement acceptables de celui-ci. Ces composés sont utiles comme inhibiteurs de la protéine HDM2. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés, et des méthodes de traitement du cancer utilisant celles-ci.
Bibliography:Application Number: CA20102777043