AUTOMATED RADIOSYNTHESIS

The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as FastlabTM. A further aspect of the invention is a cassette sui...

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Bibliographic Details
Main Authors JONES, CLARE, GAETA, ALESSANDRA, JACKSON, ALEXANDER, WOODCRAFT, JOHN, JONES, PAUL, TRIGG, WILLIAM, PLANT, STUART
Format Patent
LanguageEnglish
French
Published 14.04.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as FastlabTM. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.
Bibliography:Application Number: CA20102774031