COAGULATION FACTOR IX COMPOSITIONS AND METHODS OF MAKING AND USING SAME

• Main Authors: SPINK, BENJAMIN, SCHELLENBERGER, VOLKER, SILVERMAN, JOSHUA, GEETHING, NATHAN CARL, WANG, CHIA-WEI, TO, WAYNE, STEMMER, WILLEM PETER
• Format: Patent
• Language: English; French
• Published: 18.08.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to compositions comprising factor DC coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions. La présente invention porte sur des compositions comprenant des facteurs de coagulation DC liés à un polypeptide recombinant étendu (XTEN), sur des acides nucléiques isolés codant pour les compositions et sur des vecteurs et cellules hôtes les contenant, et sur des procédés de fabrication et d'utilisation de telles compositions dans le traitement de maladies, de troubles et d'états liés à un facteur de coagulation.