(+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhib...
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Main Authors | , , |
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Format | Patent |
Language | English French |
Published |
28.08.2018
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Abstract | The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
La présente invention concerne des (+)-morphinanes possédant une activité antagoniste des récepteurs de type Toll-9 (TLR9), ainsi que des méthodes d'utilisation desdits (+)-morphinanes pour le traitement de la douleur. L'invention concerne également des compositions d'associations pharmaceutiques comprenant un (+)-morphinane et un agoniste opioïde/un inhibiteur de la recapture des monoamines, ainsi que des méthodes d'utilisation des compositions d'associations pour le traitement de la douleur. |
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AbstractList | The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
La présente invention concerne des (+)-morphinanes possédant une activité antagoniste des récepteurs de type Toll-9 (TLR9), ainsi que des méthodes d'utilisation desdits (+)-morphinanes pour le traitement de la douleur. L'invention concerne également des compositions d'associations pharmaceutiques comprenant un (+)-morphinane et un agoniste opioïde/un inhibiteur de la recapture des monoamines, ainsi que des méthodes d'utilisation des compositions d'associations pour le traitement de la douleur. |
Author | GROTE, CHRISTOPHER W BERBERICH, DAVID W TRAWICK, BOBBY N |
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DocumentTitleAlternate | (+)-MORPHINANES EN TANT QU'ANTAGONISTES DES RECEPTEURS DE TYPE TOLL-9 ET LEURS UTILISATIONS THERAPEUTIQUES |
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Snippet | The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to... |
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SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF |
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