(+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF

The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhib...

Full description

Saved in:
Bibliographic Details
Main Authors GROTE, CHRISTOPHER W, TRAWICK, BOBBY N, BERBERICH, DAVID W
Format Patent
LanguageEnglish
French
Published 28.08.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain. La présente invention concerne des (+)-morphinanes possédant une activité antagoniste des récepteurs de type Toll-9 (TLR9), ainsi que des méthodes d'utilisation desdits (+)-morphinanes pour le traitement de la douleur. L'invention concerne également des compositions d'associations pharmaceutiques comprenant un (+)-morphinane et un agoniste opioïde/un inhibiteur de la recapture des monoamines, ainsi que des méthodes d'utilisation des compositions d'associations pour le traitement de la douleur.
Bibliography:Application Number: CA20102768199