PREPARATION OF 6-ALPHA-AMINO N-SUBSTITUTED MORPHINANS BY CATALYTIC HYDROGEN TRANSFER

The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphi-nans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer. La présente invention a pour objet des...

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Bibliographic Details
Main Authors GROTE, CHRISTOPHER W, MOSER, FRANK W, THOMASSON, CATHERINE E, MCCLURG, JOSEPH P, CANTRELL, GARY L
Format Patent
LanguageEnglish
French
Published 11.07.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphi-nans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer. La présente invention a pour objet des procédés pour la synthèse stéréosélective de morphinanes 6-alpha-amino N-substitués. En particulier, la présente invention concerne des procédés pour l'amination réductrice de morphinanes 6-céto N-substitués par transfert catalytique d'hydrogène.
Bibliography:Application Number: CA20102764915