REDUCTIVE AMINATION OF 6-KETO NORMORPHINANS BY CATALYTIC HYDROGEN TRANSFER

The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In partic-ular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation. La présente invention concerne des procédés pour la synthè...

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Bibliographic Details
Main Authors GROTE, CHRISTOPHER W, MOSER, FRANK W, THOMASSON, CATHERINE E, MCCLURG, JOSEPH P, CANTRELL, GARY L
Format Patent
LanguageEnglish
French
Published 04.04.2017
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In partic-ular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation. La présente invention concerne des procédés pour la synthèse stéréosélective de 6-alpha-amino morphinanes. En particulier, l'invention concerne des procédés permettant l'amination réductrice de 6-céto normorphinanes par hydrogénation par transfert catalytique.
Bibliography:Application Number: CA20102764884