PHARMACEUTICAL COMPOSITION CONTAINING SURFACE-COATED MICROPARTICLES

• Main Authors: KITAURA, CHIEKO, ILLUM, LISBETH, DAVIES, MARTYN C, ROBERTS, CLIVE J, OKUBO, KATSUYUKI, STOLNIK-TRENKIC, SNJEZANA, MINOMI, KENJIRO, PEARSON, ELIZABETH
• Format: Patent
• Language: English; French
• Published: 07.01.2010
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed is a pharmaceutical composition which can be used for the administration of a low-molecular-weight substance or a high-molecular-weight substance such as a peptide and a protein by a means other than injection with high efficiency.  Also disclosed is a method for producing the composition. Specifically disclosed is a pharmaceutical composition for transmucosal administration, which comprises (a) a substance which can carry a positive or negative electrical charge at a given pH value, (b) pharmaceutically acceptable microparticles, and (c) a pharmaceutically acceptable surface-coating polymer which can be electrically charged at the above-mentioned pH value.  In the composition, the surface-coating polymer coats the surfaces of the microparticles, and the substance is immobilized on the surfaces of the microparticles through the surface-coating polymer.  In the composition, the microparticles interact non-covalently with the surface-coating polymer and, at the same time, the surface-coating polymer interacts electrostatically with the substance, thereby forming a complex.