NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT

• Main Authors: BHATTACHARYA, SISIR, DEDHIYA, MAHENDRA G, RAVAUX, VALERIE, PRIOUR, ALAIN, SPARGO, PETER, DUCANDAS, VERONIQUE, BONNET, ALAIN, GIULIANI, ALEXANDRE
• Format: Patent
• Language: English; French
• Published: 27.10.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo -6-(sulphooxy)-1,6 -diazabicyclo [3 ,2 ,1] octane-2 -carboxamide (e.g., NXL-104) thereof. The present invention relates to compositions comprising a crystalline form of sodium salt of trans-7 -oxo-6-(sulphooxy)-1,6-diazabicyclo [3 ,2, 1] octane-2-carboxamide (e.g., NXL-104) alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil). Processes for the preparation of the crystalline forms and methods of treating bacterial infections by administering the crystalline forms alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil) are also described. La présente invention concerne de nouvelles formes cristallines du sel de sodium de trans-7-oxo-6-(sulfoxy)-1,6-diazabicyclo-[3,2,1]octane-2-carboxamide (p. ex., NXL-104) de celle-ci. La présente invention concerne des compositions comprenant une forme cristalline de sel sodique de trans-7-oxo-6-(sulfoxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (p. ex., NXL-104) seule ou combinée à un agent antibactérien (p. ex., ceftaroline fosamil). Des procédés de préparation de formes cristallines et des procédés de traitement dinfections bactériennes par ladministration de formes cristallines seule ou combinée à un agent antibactérien (p. ex., ceftaroline fosamil) sont également décrits.