USE OF MICROVESICLES IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF MEDICAL DISEASES AND CONDITIONS

• Main Authors: BREAKEFIELD, XANDRA O, RUSSO, LEILEATA M, SKOG, JOHAN KARL OLOV, BROWN, DENNIS, MIRANDA, KEVIN C
• Format: Patent
• Language: English; French
• Published: 12.12.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a' subject by detecting a biomarker in microvesicles isolated from a biological, sample from the subject. Moreover, disclosed subject matter is directed to methods of diagnosis, monitoring a disease by determining the concentration of microvesicles within a biological sample; methods of delivering a nucleic acid or protein to a target all by administering microvesicles that contain said nucleic acid or protein; methods for performing a body fluid transfusion by introducing a microvesicle-free or microvesicle enriched fluid fraction into a patient. Cette invention concerne des méthodes facilitant le diagnostic, le pronostic, la surveillance et lévaluation dune maladie ou autre affection médicale chez un sujet en détectant un biomarqueur dans des microvésicules isolées à partir dun échantillon biologique prélevé chez le sujet. Par ailleurs, linvention concerne des méthodes de diagnostic, de surveillance dune maladie en déterminant la concentration des microvésicules au sein dun échantillon biologique; des méthodes dintroduction dun acide nucléique ou dune protéine dans une cible en administrant des microvésicules contenant ledit acide nucléique ou ladite protéine; des méthodes dexécution dune transfusion de liquide organique en introduisant une fraction de liquide exempte de microvésicule ou enrichie en microvésicules chez un patient.