OPTIMIZED CD40 ANTIBODIES AND METHODS OF USING THE SAME

The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc.gamma.R or alters effector function as compared to the parent antibody. Also disclosed are...

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Bibliographic Details
Main Authors KARKI, SHER BAHADUR, LAZAR, GREGORY ALAN, ZHUKOVSKY, EUGENE ALEXANDER, BERNETT, MATTHEW J, CHU, SEUNG YUP, DESJARLAIS, JOHN R, PONG, ERIK WEIKING
Format Patent
LanguageEnglish
French
Published 27.10.2015
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc.gamma.R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention. La présente invention porte sur des anticorps humanisés qui ciblent CD40, les anticorps comprenant au moins une modification par rapport à un anticorps parent, la modification changeant l'affinité vis-à-vis d'un Fc?R ou changeant la fonction d'effecteur par comparaison avec l'anticorps parent. L'invention porte également sur des procédés d'utilisation des anticorps de l'invention.
Bibliography:Application Number: CA20092712989