DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS

The present invention is related to novel tricyclic compounds of formula (I) having TRPA1 receptor agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use as pharmacological tools, or as irritant incapacitants, or i...

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Bibliographic Details
Main Authors GIJSEN, HENRICUS JACOBUS MARIA, MERCKEN, MARC HUBERT
Format Patent
LanguageEnglish
French
Published 17.11.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is related to novel tricyclic compounds of formula (I) having TRPA1 receptor agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use as pharmacological tools, or as irritant incapacitants, or in the treatment of diseases linked to the modulation of the TRPA1 receptors in animals, in particular humans. La présente invention porte sur de nouveaux composés tricycliques représentés par la formule (I) ayant des propriétés agonistes des récepteurs TRPA1, sur des compositions pharmaceutiques comprenant ces composés, sur des procédés chimiques pour préparer ces composés et sur leur utilisation comme outils pharmacologiques, ou comme inhibiteurs d'irritants, ou dans le traitement de maladies liées à la modulation des récepteurs TRPA1 chez les animaux, en particulier les êtres humains.
Bibliography:Application Number: CA20082706903