IMMUNOGENIC COMPOSITIONS CONTAINING ESCHERICHIA COLI H7 FLAGELLA AND METHODS OF USE THEREOF

• Main Authors: GALLY, DAVID, NAYLOR, STUART W, MAHAJAN, ARVIND KUMAR, SMITH, DAVID GEORGE EMSLIE, MCNEILLY, TOM NATHAN, LOW, CHRIS
• Format: Patent
• Language: English; French
• Published: 05.12.2017
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli 0157:H7 flagella will result in prevention of colonization by Escherichia coli 0157:H7 in the animal or a reduction in the amount of Escherichia coli 0157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal. Cette invention concerne des compositions immunogènes contenant des flagelles d'Escherichia coli O157:H7 comprenant des protéines de fusion et des procédés utilisant lesdites compositions immunogènes. L'induction d'une réponse immunitaire aux flagelles d'Escherichia coli O157:H7 chez un animal permettra de prévenir la colonisation de l'animal par Escherichia coli O157:H7 ou de réduire la quantité d'Escherichia coli O157:H7 infectant l'animal. La composition immunogène préviendra ou réduira l'adhérence d'Escherichia coli O157:H7 aux cellules de l'animal.