PRODRUGS TO THYROID HORMONE ANALOGS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such...

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Bibliographic Details
Main Authors TILLEY, JEFFERSON WRIGHT, HAYNES, NANCY-ELLEN, SCOTT, NATHAN ROBERT
Format Patent
LanguageEnglish
French
Published 07.02.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto. L'invention porte sur des composés représentés par la formule (I) : ainsi que sur des sels et esters pharmaceutiquement acceptables de ces composés, les substituants étant tels que ceux indiqués dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies telles que l'obésité, l'hyperlépidémie, l'hypercholestérolémie et le diabète et d'autres troubles apparentés et maladies apparentées, et peuvent être utiles pour d'autres maladies telles que la NASH, l'athérosclérose, les maladies cardiovasculaires, l'hyperthyroïdisme, le cancer de la thyroïde et d'autres troubles et maladies apparentés à ceux-ci.
Bibliography:Application Number: CA20082699338