DNA-PK INHIBITORS

A compound of formula (I): wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocydyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring...

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Main Authors MENEAR, KEITH ALLAN, HUMMERSONE, MARC GEOFFREY, BAILEY, CHRISTINE SARAH, DUGGAN, HEATHER MARY ELLEN, GOMEZ, SYLVIE, MARTIN, NIALL MORRISON BARR, FRIGERIO, MARK
Format Patent
LanguageEnglish
French
Published 22.01.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (I): wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocydyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X is CH or N; n is 1 or 2; R C1 and R C2 are independently selected from H and methyl; when X is N, R x is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-20 heterocydyl, C5-20 aryl, acyl, ester, amido and sulfonyl; and when X is CH, R x is selected from the group consisting of H, and optionally substituted C1-7 alkyl, C3-2O heterocyclyl, C5-20 aryl, acyl, ester, amido, sulfonyl, amino and ether. The compounds according to formula (I) are DNA-PK inhibitors, useful in the treatment of tumours and retroviral mediated diseases.
Bibliography:Application Number: CA20082693926