CITRULLINATED FIBRIN-FILAGGRIN CHIMERIC POLYPEPTIDE CAPABLE OF DETECTING THE ANTIBODIES GENERATED IN RHEUMATOID ARTHRITIS

The present invention concerns a chimeric polypeptide, capable of detecti ng the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the .alpha. or .beta. c hain of the fibrin and (ii) a second derived from the filaggrin. In addit...

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Bibliographic Details
Main Authors GOMARA ELENA, MA JOSE, PEREZ RODRIGUEZ, MA LUISA, HARO VILLAR, ISABEL, SANMARTI SALA, RAIMON
Format Patent
LanguageEnglish
French
Published 06.11.2008
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:The present invention concerns a chimeric polypeptide, capable of detecti ng the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the .alpha. or .beta. c hain of the fibrin and (ii) a second derived from the filaggrin. In addition , the invention comprises an antigenic composition, a method and a kit for t he diagnosis of rheumatoid arthritis, from the detection of the autoantibodi es generated during the course of said disease.
Bibliography:Application Number: CA20082685756