COMPOUNDS AND METHODS FOR ENHANCING SOLUBILITY OF FLORFENICOL AND STRUCTURALLY-RELATED ANTIBIOTICS USING CYCLODEXTRINS
The relatively low solubility of florfenicol (FFC) in water (1.3mg/mL) li mits its use in medicated drinking water systems for treatment of pulmonary disease of swine and poultry. Current formulations use a high volume organic solvent to reach the required FFC concentration of 13.5mg/mL in an automa...
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Main Authors | , |
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Format | Patent |
Language | English French |
Published |
06.11.2008
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Subjects | |
Online Access | Get full text |
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Summary: | The relatively low solubility of florfenicol (FFC) in water (1.3mg/mL) li mits its use in medicated drinking water systems for treatment of pulmonary disease of swine and poultry. Current formulations use a high volume organic solvent to reach the required FFC concentration of 13.5mg/mL in an automate d proportioner mixing tank system, with practical disadvantages for the user s in the field. This invention relates to the effects of complex formation w ith natural and modified cyclodextrins on the aqueous solubility of FFC and antibiotics of related structure. Furthermore, this invention relates to the effects of polyethylene glycol (PEG-300) as a co-solvent in an FFC-cyclodex trin system to achieve the required FFC dose in the mixing tank system and t o avoid high volumes of the organic solvent. |
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Bibliography: | Application Number: CA20082685264 |