1,3,8-TRISUBSTITUTED-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE DERIVATIVES AS LIGANDS OF THE ORL-I RECEPTOR FOR THE TREATMENT OF ANXIETY AND DEPRESSION
The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. R3 is selected from the group consi...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
17.11.2015
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| Subjects | |
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| Abstract | The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. R3 is selected from the group consisting of R0 is selected from the group consisting of -CCH, hydroxy, -N3, -O-C(0)-C1-4 alkyl, -O-SO2-C1-4 alkyl, -O-(2- tetrahydropyranyl); wherein R1 is 1-ace.pi.a.rho.hthenyl; R2 is 4-fluorophenyl; A1 is selected from the group consisting of -CH2-,-CH2CH2-,-CH2CH2- and -CH2CH2CH2CH2 |
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| AbstractList | The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. R3 is selected from the group consisting of R0 is selected from the group consisting of -CCH, hydroxy, -N3, -O-C(0)-C1-4 alkyl, -O-SO2-C1-4 alkyl, -O-(2- tetrahydropyranyl); wherein R1 is 1-ace.pi.a.rho.hthenyl; R2 is 4-fluorophenyl; A1 is selected from the group consisting of -CH2-,-CH2CH2-,-CH2CH2- and -CH2CH2CH2CH2 |
| Author | BIGNAN, GILLES C RYAN, RICHARD R HLASTA, DENNIS J |
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| DocumentTitleAlternate | DERIVES DE 1,3,8-TRISUBSTITUE-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE UTILISES COMME LIGANDS DU RECEPTEUR ORL-I DANS LE TRAITEMENT DE L'ANXIETE ET DE LA DEPRESSION |
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| RelatedCompanies | JANSSEN PHARMACEUTICA NV |
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| Snippet | The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and... |
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| Title | 1,3,8-TRISUBSTITUTED-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE DERIVATIVES AS LIGANDS OF THE ORL-I RECEPTOR FOR THE TREATMENT OF ANXIETY AND DEPRESSION |
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