1,3,8-TRISUBSTITUTED-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE DERIVATIVES AS LIGANDS OF THE ORL-I RECEPTOR FOR THE TREATMENT OF ANXIETY AND DEPRESSION

The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. R3 is selected from the group consi...

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Bibliographic Details
Main Authors BIGNAN, GILLES C, RYAN, RICHARD R, HLASTA, DENNIS J
Format Patent
LanguageEnglish
French
Published 17.11.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. R3 is selected from the group consisting of R0 is selected from the group consisting of -CCH, hydroxy, -N3, -O-C(0)-C1-4 alkyl, -O-SO2-C1-4 alkyl, -O-(2- tetrahydropyranyl); wherein R1 is 1-ace.pi.a.rho.hthenyl; R2 is 4-fluorophenyl; A1 is selected from the group consisting of -CH2-,-CH2CH2-,-CH2CH2- and -CH2CH2CH2CH2
Bibliography:Application Number: CA20082683598