PROLIPOSOMAL AND LIPOSOMAL COMPOSITIONS

Concentrates or proliposomal compositions of poorly water-soluble drugs a nd compounds, comprising of one or more membrane forming lipids, a membrane stabilizing agent, in a suitable vehicle, and optionally containing a Polyet hylene Glycol (PEG)-coupled phospholipid or a mixture thereof and further...

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Main Authors GARG, MINAKSHI, JAGGI, MANU, SINGH, ANU T, MUKHERJEE, RAMA, BURMAN, ANAND C, KUMAR, MUKESH, AWASTHI, ANSHUMALI, KHATTAR, DHIRAJ
Format Patent
LanguageEnglish
French
Published 25.09.2008
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Concentrates or proliposomal compositions of poorly water-soluble drugs a nd compounds, comprising of one or more membrane forming lipids, a membrane stabilizing agent, in a suitable vehicle, and optionally containing a Polyet hylene Glycol (PEG)-coupled phospholipid or a mixture thereof and further, o ptionally containing pharmaceutically acceptable excipients such as antioxid ants, buffering agents, acidifying agents etc. are provided, which have supe rior long term stability. The concentrates of proliposomal compositions inst antly form liposomes of the said poorly water-soluble drugs and compounds on rapid injection to a diluting fluid, the liposomal composition so obtained, characterized by a physical stability more than 24 hours, >= 95% drug en capsulation and having a particle size diameter of less than 100 nm. The lip osomal compositions so obtained can further be directly administered to pati ents in need of treatment of the poorly water-soluble drugs and compounds.
Bibliography:Application Number: CA20082681302