METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY

The present invention relates generally..to heterocyclic metalloprotease inhibiting compounds of formula (I). More particularly, the present inventio n provides a new class of heterocyclic MMP 3, MMP 8 and/or MMP 13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an incr...

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Bibliographic Details
Main Authors GALLAGHER, BRIAN M., JR, GEGE, CHRISTIAN, CHEVRIER, CARINE, TAVERAS, ARTHUR
Format Patent
LanguageEnglish
French
Published 12.09.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates generally..to heterocyclic metalloprotease inhibiting compounds of formula (I). More particularly, the present inventio n provides a new class of heterocyclic MMP 3, MMP 8 and/or MMP 13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increa sed potency and selectivity in relation to currently known MMP 13, MMP 8 and MMP 3 inhibitors.
Bibliography:Application Number: CA20082680177