PEGYLATED A.BETA. FAB

• Main Authors: CHOW, CHI-KIN, KUCHIBHOTLA, UMA, HANSEN, RYAN JOHN, LU, JIRONG, MCDONNELL, PETER COLON, BALES, KELLY RENEE, BUMOL, THOMAS FRANK, DEMATTOS, RONALD BRADLEY
• Format: Patent
• Language: English; French
• Published: 30.12.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

A method to treat conditions associated with Aß peptide activity both prophylactically and therapeutically is described. The method employs humanized antibody fragments that specifically bind human Aß peptide between amino acid positions 13-28, wherein the antibody fragments are covalently attached...