PROCESS FOR THE PREPARATION OF 4-(6-CHLORO-2,3-METHYLENEDIOXYANILINO)-7-[2-(4-METHYL PIPERAZIN-1-YL)ETHOXY]-5-TETRAHYDROPYRAN-4-YLOXYQUINAZOLINE, THEIR INTERMEDIATES AND CRYSTALLINE SALTS THEREOF
The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4- methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the acti ve entity within AZD0530), to intermediates useful in the manufacture of that com...
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Format | Patent |
Language | English French |
Published |
22.06.2006
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Abstract | The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4- methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the acti ve entity within AZD0530), to intermediates useful in the manufacture of that compound and to processes for the manufacture of those intermediates. The invention also relates to particular crystalline forms of that compound such as a difumarate salt and a trihydrate and to pharmaceutical compositions containi ng such crystalline forms. |
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AbstractList | The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4- methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the acti ve entity within AZD0530), to intermediates useful in the manufacture of that compound and to processes for the manufacture of those intermediates. The invention also relates to particular crystalline forms of that compound such as a difumarate salt and a trihydrate and to pharmaceutical compositions containi ng such crystalline forms. |
Author | POINTON, SIMON MARK PURDIE, MARK O'KEARNEY-MCMULLAN, ANNE MCCABE, JAMES FRANCIS FORD, JAMES GAIR POWELL, LYN WITHNALL, JANE O'KEEFE, PHILIP |
Author_xml | – fullname: FORD, JAMES GAIR – fullname: MCCABE, JAMES FRANCIS – fullname: POINTON, SIMON MARK – fullname: WITHNALL, JANE – fullname: O'KEEFE, PHILIP – fullname: PURDIE, MARK – fullname: POWELL, LYN – fullname: O'KEARNEY-MCMULLAN, ANNE |
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DocumentTitleAlternate | METHODE DE PREPARATION DE LA 4-(6-CHLORO-2,3-METHYLENEDIOXYANILINO)-7-[2-(4-METHYLPIPERAZIN-1- YL)ETHOXY]-5-TETRAHYDROPYRAN-4-YLOXYQUINAZOLINE, D'INTERMEDIAIRES DE CE PRODUIT ET DE SELS CRISTALLINS CONNEXES |
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Snippet | The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4-... |
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Title | PROCESS FOR THE PREPARATION OF 4-(6-CHLORO-2,3-METHYLENEDIOXYANILINO)-7-[2-(4-METHYL PIPERAZIN-1-YL)ETHOXY]-5-TETRAHYDROPYRAN-4-YLOXYQUINAZOLINE, THEIR INTERMEDIATES AND CRYSTALLINE SALTS THEREOF |
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