PROCESS FOR THE PREPARATION OF 4-(6-CHLORO-2,3-METHYLENEDIOXYANILINO)-7-[2-(4-METHYL PIPERAZIN-1-YL)ETHOXY]-5-TETRAHYDROPYRAN-4-YLOXYQUINAZOLINE, THEIR INTERMEDIATES AND CRYSTALLINE SALTS THEREOF
The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4- methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the acti ve entity within AZD0530), to intermediates useful in the manufacture of that com...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English French |
Published |
22.06.2006
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4- methylpiperazin-1-yl)ethoxy]- 5-tetrahydropyran-4-yloxyquinazoline (the acti ve entity within AZD0530), to intermediates useful in the manufacture of that compound and to processes for the manufacture of those intermediates. The invention also relates to particular crystalline forms of that compound such as a difumarate salt and a trihydrate and to pharmaceutical compositions containi ng such crystalline forms. |
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Bibliography: | Application Number: CA20052675642 |