CANNABINOID RECEPTOR MODULATORS

• Main Authors: NIELSEN, PETER AADAL, LINGET, JEAN-MICHEL, HOEGBERG, THOMAS, COOPER, MARTIN, RECEVEUR, JEAN-MARIE, NOERREGAARD, PIA KARINA
• Format: Patent
• Language: English; French
• Published: 22.05.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula (I) are modulators of cannabinoid receptor CB1, usef ul for the treatment of obesity and diseases for which obesity is a risk fac tor: (I) wherein: X is a bond, Or-C(R10)(R11)-*. -C(R10)(R11)-O-*, -C(R10)(R 11)CH2-*, -C(R10)(R11)CH2-O-*, -CH2C(R10)(R11)-*, -CH2C(R10)(R11)-O-*, or -C H2-O-C(R10)(R11)-*; Y is =O, =N(R9), =N(OR9), =CH(CN), =C(CN)2 or =N(CN); Z is a bond, -O- or -NH-; R1 and R2 are hydrogen, (CrC3)alkyl, (C3-C6)cycloalk yl or monocyclic heterocyclic; or R1 and R2 taken together with the nitrogen to which they are attached form a cyclic amino ring; R3 is hydrogen or a ra dical of formula -(O)a- AIk3 wherein a and AIk3 are as defined in the claims ; R4 is a radical of formula -(O)b-(Alk1)p-(Q)r-(L)s-Q2 wherein b, p, r, s A Ik1, L, Q1 and Q2 are as defined in the claims; or R3 and R4 taken together with the nitrogen to which they are attached form a cyclic amino ring; R5 is hydrogen -F, -Cl, -Br, -CN, (C1-C3)alkyl, (C1-C3)fluoroalkyl, cyclopropyl, -COOH, tetrazole or -OR9; R6, R7 and R8 are hydrogen -F, -Cl, -Br, -CN, (C1- C3)alkyl, (C1-C3)fluoroalkyl, cyclopropyl, or -OR9; and R9 R10 and R11 are a s defined in the claims.