CANNABINOID RECEPTOR MODULATORS
Compounds of formula (I) are modulators of cannabinoid receptor CB1, usef ul for the treatment of obesity and diseases for which obesity is a risk fac tor: (I) wherein: X is a bond, Or-C(R10)(R11)-*. -C(R10)(R11)-O-*, -C(R10)(R 11)CH2-*, -C(R10)(R11)CH2-O-*, -CH2C(R10)(R11)-*, -CH2C(R10)(R11)-O-*, o...
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Main Authors | , , , , , |
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Format | Patent |
Language | English French |
Published |
22.05.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Compounds of formula (I) are modulators of cannabinoid receptor CB1, usef ul for the treatment of obesity and diseases for which obesity is a risk fac tor: (I) wherein: X is a bond, Or-C(R10)(R11)-*. -C(R10)(R11)-O-*, -C(R10)(R 11)CH2-*, -C(R10)(R11)CH2-O-*, -CH2C(R10)(R11)-*, -CH2C(R10)(R11)-O-*, or -C H2-O-C(R10)(R11)-*; Y is =O, =N(R9), =N(OR9), =CH(CN), =C(CN)2 or =N(CN); Z is a bond, -O- or -NH-; R1 and R2 are hydrogen, (CrC3)alkyl, (C3-C6)cycloalk yl or monocyclic heterocyclic; or R1 and R2 taken together with the nitrogen to which they are attached form a cyclic amino ring; R3 is hydrogen or a ra dical of formula -(O)a- AIk3 wherein a and AIk3 are as defined in the claims ; R4 is a radical of formula -(O)b-(Alk1)p-(Q)r-(L)s-Q2 wherein b, p, r, s A Ik1, L, Q1 and Q2 are as defined in the claims; or R3 and R4 taken together with the nitrogen to which they are attached form a cyclic amino ring; R5 is hydrogen -F, -Cl, -Br, -CN, (C1-C3)alkyl, (C1-C3)fluoroalkyl, cyclopropyl, -COOH, tetrazole or -OR9; R6, R7 and R8 are hydrogen -F, -Cl, -Br, -CN, (C1- C3)alkyl, (C1-C3)fluoroalkyl, cyclopropyl, or -OR9; and R9 R10 and R11 are a s defined in the claims. |
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Bibliography: | Application Number: CA20072669080 |