3-AMINO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF METABOLIC DISORDERS

• Main Authors: KULKARNI, RHUSHIKESH ARUN, PADIYA, KAMLESH JYOTINDRA, MARITA, ROSALIND ADAIKALASAMY, BAJARE, SWAPNIL RAMESH, HARIHARAN, SIVARAMAKRISHNAN, DEKA, NABAJYOTI, KHAN, TAJ USMAN
• Format: Patent
• Language: English; French
• Published: 27.03.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The picsenl invention provides novel compounds represented by the general formula (I): wherein Ar is a quinoline or isoquinoline moiety which is subs tituted or unsubstituted; B is -O. -S-. or -NH-: R1 is hydrogen or S(O)2R4: R2 is S(O)2R4. C(O)OR5. or C(O)(CH2)n-C(O)OR6: R3 is halogen, cyano, C(O)OR7 . or C(O)NR8R9: R4 is aryl: R5 is (C1-C6)alkyl or aryl: R6 is hydrogen. (C1- C4)alkyl. or aryl: R7 is hydrogen or (C1-C4)alkyl: R8 and R9 are independent ly hydrogen or (C1-C6)alkyl; n is an integer from 1-3: and a pharmaceuticall y acceptable salt or solvate thereof. their pharmaceutically acceptable salt s and their pharmaceutically acceptable solvates thereof, which are useful i n treating metabolic disorders related to insulin resistance or hyperglycemi a. The invention also relates to a process for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them.