AZA-BENZOTHIOPHENYL COMPOUNDS AND METHODS OF USE

The invention relates to azabenzothiophenyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azab enzothiophenyl compounds which inhibit MEK kinase activity. The invention pr ovides compositions and methods useful for inhibiting abnormal cell growt...

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Main Authors PRICE, STEPHEN, MONTANA, JOHN GARY, BAO, LIANG, STANLEY, MARK S, SAVY, PASCAL PIERRE, WILLIAMS, KAREN, DYKE, HAZEL JOAN
Format Patent
LanguageEnglish
French
Published 28.02.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to azabenzothiophenyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azab enzothiophenyl compounds which inhibit MEK kinase activity. The invention pr ovides compositions and methods useful for inhibiting abnormal cell growth o r treating a hyperproliferative disorder, or treating an inflammatory diseas e in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells , or associated pathological conditions.
Bibliography:Application Number: CA20072660963