DISEASE MODEL INCORPORATION INTO AN ARTIFICIAL IMMUNE SYSTEM (AIS)

• Main Authors: FAHLENKAMP, HEATHER, RIVARD, MICHAEL, MISHKIN, ERIC, SANCHEZ-SCHMITZ, GUZMAN, HIGBEE, RUSSELL, WARREN, WILLIAM L
• Format: Patent
• Language: English; French
• Published: 11.10.2016
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologies and other chemicals. La présente invention concerne des procédés de préparation d'un système immunitaire artificiel. Le système immunitaire artificiel est constitué d'une culture cellulaire qui comporte une matrice tridimensionnelle contenant un tissu lymphoïde, une matrice tridimensionnelle contenant des cellules épithéliales et/ou endothéliales, et des cellules malades. Le système immunitaire artificiel de la présente invention peut être utilisé pour des essais in vitro de vaccins, d'adjuvants, de candidats immunothérapeutiques, de produits cosmétiques, de médicaments, de processus biologiques et autres substances chimiques.