ANTI-COCAINE COMPOSITIONS AND TREATMENT

Embodiments of the invention disclosed herein generally relate to anti-co caine therapeutics. Specifically, some embodiments of the invention relate t o highly efficient, thermostable, and long-lasting cocaine esterase (CocE) m utants that can protect against the toxic and reinforcing effects of coc...

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Main Authors DENG, SHI-XIAN, MACDONALD, JOANNE, ZHAN, CHANG-GUO, GAO, DAQUAN, LEE, TIEN-YI, KO, MEIUAN HOLDEN, KWON, YOUNG MIN, WOODS, JAMES H, SUNAHARA, ROGER, YANG, VICTOR, TESMER, JOHN J, LANDRY, DONALD, NARASIMHAN, DIWAHAR L
Format Patent
LanguageEnglish
French
Published 17.01.2008
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Embodiments of the invention disclosed herein generally relate to anti-co caine therapeutics. Specifically, some embodiments of the invention relate t o highly efficient, thermostable, and long-lasting cocaine esterase (CocE) m utants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermo stable esterase activity. Also provided are methods of treating cocaine-indu ced conditions in a subject in need via administration of mutant CocE as wel l as methods for high-throughput screening of candidate esterase polypeptide s.
Bibliography:Application Number: CA20072657246