HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatm...
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| Main Authors | , , , , , , , , , , , , , , |
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| Format | Patent |
| Language | English French |
| Published |
12.09.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
La présente invention concerne des composés répondant à la Formule (I), y compris des énantiomères résolus, des diastéréoisomères résolus, des solvates, et leurs sels pharmaceutiquement acceptables. La présente invention concerne également des procédés d'utilisation des composés en tant qu'inhibiteurs de la protéine kinase AKT et pour le traitement de maladies hyperproliférantes telles que le cancer. |
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| AbstractList | The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
La présente invention concerne des composés répondant à la Formule (I), y compris des énantiomères résolus, des diastéréoisomères résolus, des solvates, et leurs sels pharmaceutiquement acceptables. La présente invention concerne également des procédés d'utilisation des composés en tant qu'inhibiteurs de la protéine kinase AKT et pour le traitement de maladies hyperproliférantes telles que le cancer. |
| Author | WALLACE, ELI M SAFINA, BRIAN ZHANG, BIRONG DO, STEVEN BANKA, ANNA L SCHLACHTER, STEPHEN T KALLAN, NICHOLAS C LIANG, JUN BENCSIK, JOSEF R XIAO, DENGMING CHABOT, CHRISTINE XU, RUI BLAKE, JAMES F SPENCER, KEITH LEE MITCHELL, IAN S |
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| DocumentTitleAlternate | PYRIMIDINES CYCLOPENTA [D] HYDROXYLES ET METHOXYLES UTILISES EN TANT QU'INHIBITEURS DE LA PROTEINE KINASE AKT |
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| Snippet | The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof,... |
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| Title | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS |
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