HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatm...

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Main Authors CHABOT, CHRISTINE, ZHANG, BIRONG, BLAKE, JAMES F, DO, STEVEN, SPENCER, KEITH LEE, LIANG, JUN, WALLACE, ELI M, XIAO, DENGMING, BENCSIK, JOSEF R, XU, RUI, KALLAN, NICHOLAS C, MITCHELL, IAN S, BANKA, ANNA L, SAFINA, BRIAN, SCHLACHTER, STEPHEN T
Format Patent
LanguageEnglish
French
Published 12.09.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer. La présente invention concerne des composés répondant à la Formule (I), y compris des énantiomères résolus, des diastéréoisomères résolus, des solvates, et leurs sels pharmaceutiquement acceptables. La présente invention concerne également des procédés d'utilisation des composés en tant qu'inhibiteurs de la protéine kinase AKT et pour le traitement de maladies hyperproliférantes telles que le cancer.
Bibliography:Application Number: CA20072656622