A PROCESS FOR THE PREPARATION OF POLY-ALPHA-GLUTAMIC ACID AND DERIVATIVES THEREOF

The invention relates to an improved process for the preparation of poly-.alpha.-glutamic acids which comprises the polymerisation of tertiary .gamma.-esters of .alpha.-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-.alph...

Full description

Saved in:
Bibliographic Details
Main Authors GRUGNI, MARIO, ARTICO, MARCO, PARDI, GIANLUCA, FELICIOTTI, LUCA, DA RE, GIOVANNI, MCKENNON, MARC
Format Patent
LanguageEnglish
French
Published 09.12.2014
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
Online AccessGet full text

Cover

More Information
Summary:The invention relates to an improved process for the preparation of poly-.alpha.-glutamic acids which comprises the polymerisation of tertiary .gamma.-esters of .alpha.-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-.alpha.-glutamic acid-.gamma.-ester. The process is particularly advantageous in that it allows to carefully control the molecular weight of the resulting poly-.alpha.-glutamic acid. The invention also relates to poly-.alpha.-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.
Bibliography:Application Number: CA20072656077