PSEUDO PROLINE DIPEPTIDES

Disclosed is a three step process for the manufacture of pseudo proline d ipeptides of the formula (I) wherein R1 is a side chain of an alpha amino ac id , R2 is an amino protecting group and R3 and R4 are independently selecte d from hydrogen or C1-4-alkyl, R5 is hydrogen or methyl starting from an...

Full description

Saved in:
Bibliographic Details
Main Authors GOETZOE, STEPHAN, AMMANN, THOMAS, WELZ, SANDRA, WOLTER, KLAUS-JUERGEN, THERN, BERND
Format Patent
LanguageEnglish
French
Published 03.01.2008
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online AccessGet full text

Cover

More Information
Summary:Disclosed is a three step process for the manufacture of pseudo proline d ipeptides of the formula (I) wherein R1 is a side chain of an alpha amino ac id , R2 is an amino protecting group and R3 and R4 are independently selecte d from hydrogen or C1-4-alkyl, R5 is hydrogen or methyl starting from an ami no acid derivative of the formula (II) wherein R1 and R2 are as above. Pseud o proline dipeptides can be used as reversible protecting groups for Ser, Th r and Cys and thus are versatile tools in peptide chemistry.
Bibliography:Application Number: CA20072654914