SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF

The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modul...

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Main Authors READER, VALERIE, WILSON, FRANCIS, MAJOR, JEREMY, SMELT, KATHRYN, BOUSSARD, CYRILLE, TAYLOR, JESS, BURCKHARDT, SVENJA, ZHANG, YAN, LEFORMAL, ADELINE, HERNADEZ-PERNI, REMEDIOS, REID, ALISON, HO, CHIH YUNG, HARRISON, RICHARD JOHN, SUNOSE, MIHIRO, CANSFIELD, ANDREW
Format Patent
LanguageEnglish
French
Published 23.08.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of .gamma.-secretase activity, wherein A is O, NH, S; X is a bond or a group -CR5R6 .UPSILON. is a carboxy group -C(O)OH or a substituted or unsubstituted tetrazole group..
Bibliography:Application Number: CA20072650006