PHL P 1 ALLERGEN DERIVATIVE

• Main Authors: LINHART, BIRGIT, VALENT, PETER, BALL, TANJA, LUPINEK, CHRISTIAN, THALHAMER, JOSEF, VALENTA, RUDOLF, STOECKLINGER, ANGELIKA
• Format: Patent
• Language: English; French
• Published: 08.11.2007
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Producing derivatives of wild-type protein allergen Phl p 1 with reduced allergenic activity compared to the wild-type allergen comprises providing wild-type protein allergen Phl p 1; fragmenting the wild-type protein allergen into at least three fragments, where at least one fragment comprises at least one T-cell epitope and the three fragments have a reduced allergenic activity or lack allergenic activity; and rejoining the three fragments in an order differing from the order of the fragments in the wild-type allergen. Independent claims are: (1) an allergen derivative obtainable by the method above; (2) an allergen derivative of wild-type protein allergen Phl p 1, where the derivative contains at least three fragments of the wild-type protein allergen fused to each other in an order differing from the order of the fragments in the wild-type allergen, where the three wild-type allergen fragments exhibit reduced allergenic activity or lack allergenic activity, and where at least one of the fragments comprises one or more T cell epitopes; (3) an allergen composition comprising an allergen derivative and allergens, preferably wild-type allergens, especially a mixture of wild-type allergens, recombinant wild-type allergens, and/or derivatives of wild-type protein allergens; and (4) a method for producing an allergen derivative. ACTIVITY : Antiallergic. No biological data given. MECHANISM OF ACTION : Vaccine.