GENE DISRUPTONS, COMPOSITIONS AND METHODS RELATING THERETO

• Main Authors: SPARKS, MARY JEAN, SEVAUX, TRACY ELLEN WILLIS, MINZE, LAURIE JEANETTE, CUNNINGHAM, JAIME-JO, CULBERTSON, LING LING, SHI, ZHENG-ZHENG, MCLAIN, DINA REBECCA, MONTGOMERY, CHARLES A, VOGEL, PETER, TOWNSEND, TERESA GAIL, COMBS, KATHERIN E, STALA, JOY ANNE, PHILLIPS, HEIDI, HORNER, ALLISON ANNE BYERS, PAYNE, BOBBY JOE, BOLLINGER, KRISTI RAE, EDWARDS, JOEL, GREEN, LESLIE, GIRGIS, ROSEMARY, DESAUVAGE, FREDERIC, TANG, TRACY TZU-LING
• Format: Patent
• Language: English; French
• Published: 11.10.2007
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; TESTING; TRAPPING

The present invention relates to transgenic animals, as wells as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PR021184, PRO7434, PRO9822, PRO8933, PRO9836, PRO9854, PRO9863, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration, or correction of diseases or dysfunctions associated with gene disruptions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorder; or developmental abnormalities.