PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is a group of Formula (II) and salts thereof. Such pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also rela...

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Main Authors ARCARI, JOEL THOMAS, XIAO, JUN, LUZZIO, MICHAEL JOSEPH, SOUTHERS, JAMES ALFRED, JR, BHATTACHARYA, SAMIT KUMAR, BROSIUS, ARTHUR DOUGLAS, PAN, GONGHUA, NELSON, KENDRA LOUISE, WISHKA, DONN GREGORY
Format Patent
LanguageEnglish
French
Published 10.04.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein Ar is a group of Formula (II) and salts thereof. Such pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Bibliography:Application Number: CA20062634646