NOVEL COMPOUNDS AND METHODS FOR FORMING TAXANES AND USING THE SAME

The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds. More particularly, the present embodiments disclosed herein relate to novel side chains, that when coupled to a taxane, are useful for the synthesis of pharmaceutically useful taxa...

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Main Authors VENKATARAMAN, SYLESH, YIANNIKOUROS, GEORGE PETROS, MCCHESNEY, JAMES D, HENRI, JOHN T, STEMPHOSKI, AARON MICHAEL, SUMNER, CHRISTIAN, WALKER, DONALD G
Format Patent
LanguageEnglish
French
Published 28.06.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds. More particularly, the present embodiments disclosed herein relate to novel side chains, that when coupled to a taxane, are useful for the synthesis of pharmaceutically useful taxanes. Methods of forming the novel side chains and coupling them to hindered alcohols, namely taxanes resulting in useful esters are also disclosed. Various taxanes compounds are known to exhibit anti-tumor activity.
Bibliography:Application Number: CA20052634453