IMMUNO-RNA-CONSTRUCTS

• Main Authors: BARTH, STEFAN, NEEF, INGA, WUELLNER, ULRICH
• Format: Patent
• Language: English; French
• Published: 06.03.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the invention are also medicaments comprising the compound and their use as a medicament for the treatment of diseases, including proliferative diseases. L'invention se rapporte à un composé comprenant une fraction de ciblage qui se lie de manière spécifique à un marqueur de surface cellulaire dont la présence est liée à une maladie, un acide nucléique qui induit une mort cellulaire de manière spécifique, ainsi qu'un lieur. Selon l'invention, ce lieur établit une liaison covalente entre la fraction de ciblage et l'acide nucléique. Cette invention concerne en outre des médicaments qui comprenent ledit composé, ainsi que leur utilisation pour traiter des maladies parmi lesquelles figurent des maladies prolifératives.