FOUR BRANCHED DENDRIMER-PEG FOR CONJUGATION TO PROTEINS AND PEPTIDES

A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: (see above formula) The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-l...

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Main Authors RAMON HERNANDEZ, JOSE ANGEL, CASTRO ODIO, FIDEL RAUL, SAEZ MARTINEZ, VIVIAN MARIA, FERNANDEZ SANCHEZ, EDUARDO, PAEZ MEIRELES, ROLANDO
Format Patent
LanguageEnglish
French
Published 16.07.2013
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: (see above formula) The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability. L'invention concerne une structure polymère semblable à un dendrimère à quatre branches de monométoxypolyétylèneglycol susceptible d'être représentée comme suit: le groupe carboxylique de la structure antérieure peut être fonctionnalisé pour l'obtention de conjugués à intérêt pharmaceutique. L'union de ce polyéthylèneglycol semblable à des dendrimères avec des protéines thérapeutiques améliore la stabilité in vitro et in vivo de celles-ci.
Bibliography:Application Number: CA20062631335