COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS

• Main Authors: WU, LAURENCE, BAR-HAIM, SHAY, MOHANTY, PRADYUMNA, HEIFETZ, ALEXANDER, MARANTZ, YAEL, NOIMAN, SILVIA, BECKER, OREN M, CHEN, DONGLI, LOBERA, MERCEDES, SHACHAM, SHARON, DHANOA, DALE S, INBAL, BOAZ
• Format: Patent
• Language: English; French
• Published: 12.08.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention generally relates to thienopyridinone 5-HT4 receptor modulators, and in particular the use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin action, such as in treating Alzheimer's disease, cognition disorders, depression, and anxiety. La présente invention concerne d'une manière générale des modulateurs du récepteur de la thiénopyridinone 5-HT4 et en particulier l'utilisation de ces composés et de leurs compositions pharmaceutiques, par exemple pour le traitement, la modulation et/ou la prévention d'états physiologiques associés à l'action de la sérotonine tels que la maladie d'Alzheimer, les troubles de la cognition, la dépression et l'anxiété.