ASPARTIC PROTEASE INHIBITORS

• Main Authors: CLAREMON, DAVID A, TICE, COLIN, FLAHERTY, PATRICK T, YUAN, JING, SIMPSON, ROBERT D, ISHCHENKO, ALEXEY V, SINGH, SURESH B, XU, ZHENRONG, DILLARD, LAWRENCE W, MCGEEHAN, GERARD, BALDWIN, JOHN J, ZHAO, WEI, CACATIAN, SALVACION
• Format: Patent
• Language: English; French
• Published: 21.06.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic protease s in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.