IMPROVED NANOBODIES AGAINST TUMOR NECROSIS FACTOR-ALPHA

• Main Author: BEIRNAERT, ELS
• Format: Patent
• Language: English; French
• Published: 30.05.2017
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to improved Nanobodies~ against Tumor Necrosis Factor-alpha (TNF-alpha), as well as to polypeptides comprising or essentially consisting of one or more of such Nanobodies. The invention also relates to nucleic acids encoding such Nanobodies and polypeptides; to methods for preparing such Nanobodies and polypeptides; to host cells expressing or capable of expressing such Nanobodies or polypeptides; to compositions comprising such Nanobodies, polypeptides, nucleic acids or host cells; and to uses of such Nanobodies, such polypeptides, such nucleic acids, such host cells or such compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes. La présente invention concerne des nanocorps~ améliorés utilisés contre le facteur-alpha de nécrose tumorale (TNF-alpha), ainsi que des polypeptides comprenant ou essentiellement composés d'un ou de plusieurs nanocorps. L'invention concerne également des acides nucléiques codant pour lesdits nanocorps et polypeptides; des méthodes de préparation desdits nanocorps et polypeptides; des cellules hôtes exprimant ou pouvant exprimer lesdits nanocorps ou polypeptides; des compositions contenant lesdits nanocorps, polypeptides, acides nucléiques ou cellules hôtes; et les utilisations desdits nanocorps, polypeptides, acides nucléiques, cellules hôtes ou compositions, en particulier à des fins prophylactiques, thérapeutiques ou diagnostiques.